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[继发性甲状旁腺功能亢进与多发性椎体棕色瘤:甲状旁腺切除术后治愈]

[Secondary hyperparathyroidism and multiple vertebral brown tumors: cure after parathyroidectomy].

作者信息

Kharrat M, Turc Baron C, Djamali A, Delmas S, Lopez S, Deschodt G, Mourad G

机构信息

Service de néphrologie, Nîmes.

出版信息

Nephrologie. 1997;18(4):129-32.

PMID:9380247
Abstract

A 46 year old man was referred for severe left cruralgia and multiple vertebral cystic defects on CT-scan. He was treated by hemodialysis since 1987 for chronic renal failure secondary to focal and segmental glomerulosclerosis, diagnosed in 1960 on renal biopsy. Dialysis schedule consisted of 3 x 4 h/week with a polysulfone dialyser and 1.75 mMol Ca containing bicarbonate dialysate. On early 1995, the patient complained of back pain and cruralgia, which gradually worsened. Vertebral column CT-scan and MRI showed multiple lytic lesions expanding into the medullary canal. Biological hyperparathyroidism was present. To differentiate between hyperparathyroidism with brown tumors, malignancy and amyloid deposition, an iliac biopsy and a biopsy of a corporeal vertebral cyst were done. They showed florid hyperparathyroidism and brown tumors. The patient was submitted to surgical parathyroidectomy. Six months after surgery, cruralgia resumed, CT-scan and MRI showed refilling of the cysts by calcic material.

摘要

一名46岁男性因严重的左侧小腿疼痛和CT扫描显示的多个椎体囊性缺损而前来就诊。自1987年以来,他因1960年肾活检诊断为局灶节段性肾小球硬化继发的慢性肾衰竭接受血液透析治疗。透析方案为每周3次,每次4小时,使用聚砜透析器和含钙1.75毫摩尔的碳酸氢盐透析液。1995年初,患者抱怨背部疼痛和小腿疼痛,且逐渐加重。脊柱CT扫描和MRI显示多个溶骨性病变扩展至髓腔。存在生物性甲状旁腺功能亢进。为了鉴别甲状旁腺功能亢进伴棕色瘤、恶性肿瘤和淀粉样沉积,进行了髂骨活检和椎体囊性病变活检。结果显示为活跃的甲状旁腺功能亢进和棕色瘤。患者接受了甲状旁腺手术切除。术后6个月,小腿疼痛复发,CT扫描和MRI显示囊肿被钙质物质充填。

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