Grau E, Real E, Perella M, Escandon J, Pastor E, Gómez A
Servicio de Hematología-Hemoterapia, Hospital Lluís Alcanyís, Xàtiva, Valencia, España.
Sangre (Barc). 1997 Jun;42(3):231-3.
A patient with an atypical clinical presentation of cutaneous B-cell lymphoma is reported. He showed a rapidly growing tumour with areas of skin necrosis, haemorrhage, ulceration and suppuration in his upper back. There were involvement of contiguous anatomic site and extracutaneous spread. The histology showed diffuse lymphoid infiltration of the dermis. The cell morphology was that of a monotonous population of centroblasts. Treatment with CHOP and radiotherapy provided long-term complete remission. This case illustrates that primary cutaneous B-cell lymphoma may behave as a high-grade malignancy. Vigorous treatment with chemotherapy and radiotherapy is recommended in such cases.
报告了一例皮肤B细胞淋巴瘤临床表现不典型的患者。他的上背部出现一个快速生长的肿瘤,伴有皮肤坏死、出血、溃疡和化脓区域。存在相邻解剖部位受累及皮肤外扩散。组织学显示真皮弥漫性淋巴细胞浸润。细胞形态为清一色的中心母细胞。采用CHOP方案化疗及放疗后实现了长期完全缓解。该病例表明原发性皮肤B细胞淋巴瘤可能表现为高级别恶性肿瘤。对于此类病例,建议积极采用化疗和放疗进行治疗。