重组起始：像A、B、C、D……契位点一样简单？

Recombination initiation: easy as A, B, C, D... chi?

作者信息

Eggleston A K, West S C

机构信息

Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.

出版信息

Curr Biol. 1997 Dec 1;7(12):R745-9. doi: 10.1016/s0960-9822(06)00394-0.

DOI:10.1016/s0960-9822(06)00394-0

PMID:9382825

Abstract

The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-containing DNA.

摘要

八聚体χ（chi）序列是大肠杆菌中的一个重组热点。最近的研究提出了一种独特的机制，通过该机制，χ不仅调节RecBCD酶的核酸酶活性，还调节RecBCD将链交换蛋白RecA加载到含χ的DNA上的能力。