Bayley H
Department of Medical Biochemistry and Genetics, Texas A&M Health Science Center, 440 Reynolds Medical Building, College Station, Texas 77843-1114, USA.
Curr Biol. 1997 Dec 1;7(12):R763-7. doi: 10.1016/s0960-9822(06)00399-x.
The structure of the monomeric form of perfringolysin O solved by X-ray crystallography has been used to model the very large transmembrane pore formed when this bacterial protein toxin assembles in cholesterol-containing membranes. The structure is a notable advance, but it may not provide the whole story.