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Toxin structure: part of a hole?

作者信息

Bayley H

机构信息

Department of Medical Biochemistry and Genetics, Texas A&M Health Science Center, 440 Reynolds Medical Building, College Station, Texas 77843-1114, USA.

出版信息

Curr Biol. 1997 Dec 1;7(12):R763-7. doi: 10.1016/s0960-9822(06)00399-x.

Abstract

The structure of the monomeric form of perfringolysin O solved by X-ray crystallography has been used to model the very large transmembrane pore formed when this bacterial protein toxin assembles in cholesterol-containing membranes. The structure is a notable advance, but it may not provide the whole story.

摘要

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