有得有失：弱分子间相互作用中的焓-熵补偿

Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions.

作者信息

Dunitz J D

机构信息

Organic Chemistry Laboratory, Swiss Federal Institute of Technology, Zürich, Switzerland.

出版信息

Chem Biol. 1995 Nov;2(11):709-12. doi: 10.1016/1074-5521(95)90097-7.

DOI:10.1016/1074-5521(95)90097-7

PMID:9383477

Abstract

Enthalpy-entropy compensation is a general feature of many chemical reactions and processes in biological systems, but its origin has remained obscure. A simple thermodynamic argument suggests that enthalpy-entropy compensation is a general property of weak intermolecular interactions, and that the two contributions to the free energy should nearly balance out for a hydrogen bond at 300 K.

摘要

焓-熵补偿是生物系统中许多化学反应和过程的一个普遍特征，但其起源一直不明。一个简单的热力学观点表明，焓-熵补偿是弱分子间相互作用的一个普遍特性，并且在300 K时，氢键对自由能的这两种贡献应该几乎相互抵消。