过氧化物酶体增殖物激活受体γ：脂肪生成和全身胰岛素敏感性的关键调节因子。

Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.

作者信息

Spiegelman B M

机构信息

Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

出版信息

Eur J Med Res. 1997 Nov 28;2(11):457-64.

PMID:9385114

Abstract

The adipose cell is now known to play a complex role in energy homeostasis, storing energy and signaling to other tissues concerning the state of energy balance. The past several years have seen an explosive increase in our knowledge of the transcriptional basis of adipocyte differentiation. This review describes the role of peroxisome proliferator-activated receptor gamma in this process, and describes how other transcription factors may affect adipogenesis by modulating PPARgamma amount or activity. Furthermore, PPARgamma and other adipogenic transcription factors provide a focus for beginning to understand how various hormones and metabolites influence the development of this tissue in vivo.

摘要

现在已知脂肪细胞在能量稳态中发挥着复杂的作用，储存能量并向其他组织传递有关能量平衡状态的信号。在过去几年中，我们对脂肪细胞分化的转录基础的认识呈爆发式增长。本综述描述了过氧化物酶体增殖物激活受体γ在此过程中的作用，并描述了其他转录因子如何通过调节PPARγ的量或活性来影响脂肪生成。此外，PPARγ和其他脂肪生成转录因子为开始理解各种激素和代谢物如何在体内影响该组织的发育提供了一个重点。