MMWR Morb Mortal Wkly Rep. 1997 Nov 14;46(45):1066-9.
In 1997, a nongovernmental surveillance group for Creutzfeldt-Jakob disease (CJD) in Japan reported to the Ministry of Health and Welfare its analysis of a 1996 mail questionnaire survey of neurologic, psychiatric, and neuropathologic institutions throughout Japan. This analysis identified 829 patients with CJD diagnosed by physicians during January 1979-May 1996, including a large number (43 patients) who had received a cadaveric dura mater graft during a neurosurgical (42) or orthopedic (one) procedure during 1979-1991. This report presents a summary of features of these 43 cases, which indicated that at least 41 of these patients had received dura mater grafts from the same processor, and describes CJD in the most recent recipient of a dura mater graft. The findings indicate that an international outbreak of CJD associated with a single brand of dura mater grafts is larger than previously recognized and that recipients of contaminated grafts may remain at risk for CJD at least 16 years following receipt of grafts.
1997年，日本克雅氏病（CJD）非政府监测组织向厚生省报告了其对1996年一项针对日本全国神经科、精神科和神经病理学机构的邮件问卷调查的分析结果。该分析确定了1979年1月至1996年5月期间由医生诊断出的829例克雅氏病患者，其中包括大量（43例）在1979年至1991年期间接受过神经外科手术（42例）或骨科手术（1例）时使用尸体硬脑膜移植的患者。本报告总结了这43例病例的特征，表明这些患者中至少有41例接受了来自同一加工商的硬脑膜移植，并描述了最近接受硬脑膜移植患者的克雅氏病情况。研究结果表明，与单一品牌硬脑膜移植相关的克雅氏病国际疫情规模比此前认识到的更大，且受污染移植的接受者在接受移植后至少16年内仍有感染克雅氏病的风险。
