Nasu K, Arima K, Yoshimatsu J, Miyakawa I
Department of Obstetrics and Gynecology, Oita Medical University, Japan.
Jpn J Clin Oncol. 1997 Oct;27(5):350-2. doi: 10.1093/jjco/27.5.350.
We report a case of adenomyomatous polyp that developed during treatment with tamoxifen for breast cancer. A 63-year-old Japanese woman was admitted complaining of atypical genital bleeding. Nine months earlier, she had undergone a modified radical mastectomy for cancer of her right breast, estrogen receptor-positive stage I (T1N0M0). The administration of tamoxifen, 20 mg/day, was started immediately postoperatively. Pelvic examination after tamoxifen administration for 9 months revealed that the uterus was enlarged to the size of a fist. Transvaginal ultrasonography and magnetic resonance imaging revealed a large solid mass with multiple cystic areas in the uterine cavity. The pathological diagnosis of the tumor after total hysterectomy was typical adenomyomatous polyp. It was believed to have developed during tamoxifen administration.
我们报告一例在他莫昔芬治疗乳腺癌期间发生的腺肌瘤样息肉病例。一名63岁的日本女性因非典型生殖器出血入院。九个月前，她因右乳腺癌接受了改良根治性乳房切除术，雌激素受体阳性I期（T1N0M0）。术后立即开始每天服用20mg他莫昔芬。服用他莫昔芬9个月后的盆腔检查发现子宫增大至拳头大小。经阴道超声检查和磁共振成像显示子宫腔内有一个大的实性肿块，伴有多个囊性区域。全子宫切除术后肿瘤的病理诊断为典型的腺肌瘤样息肉。据信是在服用他莫昔芬期间发生的。
