Akin C, Hansen P, Janckila A
Medical Service, Department of Veterans Affairs Medical Center, Louisville, KY, USA.
J Ky Med Assoc. 1997 Nov;95(11):465-7.
A patient with B-cell prolymphocytic leukemia (PLL) who has had a prolonged survival is presented. The patient was diagnosed incidentally while asymptomatic, but later developed progressive disease. He was refractory to alkylating agents and fludarabine, but responded to treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone. This patient's prolonged survival may be due partly to his diagnosis at an indolent phase, possibly representing the early phase of the natural course of the disease. Diagnosis, clinical course, and treatment options for PLL are discussed.
报告了一名患有B细胞原淋巴细胞白血病（PLL）且生存期延长的患者。该患者在无症状时偶然被诊断出，但后来病情进展。他对烷化剂和氟达拉滨耐药，但对环磷酰胺、阿霉素、长春新碱和泼尼松治疗有反应。该患者生存期延长可能部分归因于其在惰性期被诊断，这可能代表了疾病自然病程的早期阶段。文中讨论了PLL的诊断、临床病程及治疗选择。
