Coelho P M, Lima e Silva F C, Nogueira-Machado J A
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brasil.
Rev Inst Med Trop Sao Paulo. 1997 Mar-Apr;39(2):101-6. doi: 10.1590/s0036-46651997000200007.
A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the strains R1 and LE (standard), showed an evident resistance to the drug in worms of the strain R1. Thus, at the dose of 250 mg/kg oxamniquine, all mice (17) infected with the LE strain did not show surviving worms, whereas 12 out of 17 mice infected with the R1 strain presented surviving worms. At the dose of 200 mg/kg, the LE strain showed recovery rates of 1.06% and 20.58%, whereas the R1 strain presented 18.57% and 61.14%, for male and female worms, respectively. At the dose of 100 mg/kg, the recovery of male worms was 2.6% for the LE strain, and 29.9% for the R1 strain. At the same dose, the recovery of females did not show statistically significant differences between the two strains (LE = 76.38%, R1 = 79.12%). Praziquantel showed similar antischistosomal activity against both studied strains, when administered at the dose of 500 mg/kg.
一株曼氏血吸虫（R1）从一名曾接受过四次奥沙尼喹治疗和一次吡喹酮治疗的患者体内分离出来。对感染R1株和LE株（标准株）的小鼠使用奥沙尼喹进行化疗试验的结果显示，R1株的虫体对该药物具有明显抗性。因此，在奥沙尼喹剂量为250mg/kg时，所有感染LE株的小鼠（17只）均未发现存活虫体，而感染R1株的17只小鼠中有12只出现了存活虫体。在剂量为200mg/kg时，LE株雄虫和雌虫的恢复率分别为1.06%和20.58%，而R1株雄虫和雌虫的恢复率分别为18.57%和61.14%。在剂量为100mg/kg时，LE株雄虫的恢复率为2.6%，R1株为29.9%。在相同剂量下，两株雌虫的恢复率无统计学显著差异（LE = 76.38%，R1 = 79.12%）。当以500mg/kg的剂量给药时，吡喹酮对两种研究株显示出相似的抗血吸虫活性。
