Clattenburg R N, Donnelly C L
Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
J Am Acad Child Adolesc Psychiatry. 1997 Nov;36(11):1606-8. doi: 10.1016/S0890-8567(09)66572-2.
The development of acute neuropsychiatric symptoms in a 10-year-old boy subsequent to his return from travel abroad in Africa, where he had taken the antimalarial agent mefloquine (Lariam), is reported. A 4-week course of cognitive-behavioral therapy was used to effectively treat this substance-induced anxiety disorder, which had been caused by treatment with mefloquine. A review of the literature about adverse neuropsychiatric effects of mefloquine and the differential diagnosis of malaria is provided. In an age in which international travel is occurring with increasing frequency, it is important to obtain travel histories, including exposure to prophylactic medication, when patients present with acute-onset psychiatric symptoms.
据报告，一名10岁男孩从非洲旅行回国后出现急性神经精神症状，他在非洲期间服用了抗疟药甲氟喹（Lariam）。采用了为期4周的认知行为疗法有效治疗这种由甲氟喹治疗引起的物质所致焦虑障碍。本文还提供了关于甲氟喹不良神经精神效应及疟疾鉴别诊断的文献综述。在国际旅行日益频繁的时代，当患者出现急性起病的精神症状时，获取旅行史，包括预防性用药情况，非常重要。
