Byrne C D, Wareham N J, Phillips D I, Hales C N, Martensz N D
University Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK.
Diabet Med. 1997 Nov;14(11):942-50. doi: 10.1002/(SICI)1096-9136(199711)14:11<942::AID-DIA500>3.0.CO;2-B.
To investigate whether individual component features of the insulin resistance syndrome were associated with the postprandial triglyceride response, 57 healthy Caucasian men between 57 and 70 years of age underwent a fat tolerance test lasting 8 h. Fasting triglyceride concentrations were associated with the total unfractionated postprandial triglyceride response (r(s) = 0.54, p < 0.001) and the triglyceride-rich lipoprotein (TGRLP) fraction (d < 1.006) at 8 h was associated with the maximum non-esterified fatty acid concentration (NEFA) (r(s) = 0.33, p = 0.01). Measures of obesity (BMI and WHR) were not associated with the postprandial triglyceride response but were inversely related to NEFA suppression (NEFA nadir and BMI, r(s) = 0.31, p = 0.02; and NEFA nadir and WHR, r(s) = 0.36, p = 0.006). Other component features of the IRS, including glucose tolerance and two proxy measures of insulin resistance (fasting insulin concentration and HOMA measurement) were not associated with the postprandial triglyceride response despite being strongly associated with fasting triglyceride concentration. Current smoking habit, chronic alcohol consumption and birth weight were also not associated with an altered postprandial triglyceride response. In conclusion these results show that although component features of the IRS were associated with increased fasting triglyceride concentrations many of these features, including two proxy measures of insulin sensitivity were not associated with an exaggerated postprandial triglyceride response.
为了研究胰岛素抵抗综合征的各个组成特征是否与餐后甘油三酯反应相关，57名年龄在57至70岁之间的健康白种男性接受了一项持续8小时的脂肪耐量试验。空腹甘油三酯浓度与餐后未分级甘油三酯的总反应相关（r(s)=0.54，p<0.001），8小时时富含甘油三酯的脂蛋白（TGRLP）部分（d<1.006）与最大非酯化脂肪酸浓度（NEFA）相关（r(s)=0.33，p=0.01）。肥胖指标（BMI和WHR）与餐后甘油三酯反应无关，但与NEFA抑制呈负相关（NEFA最低点与BMI，r(s)=0.31，p=0.02；NEFA最低点与WHR，r(s)=0.36，p=0.006）。胰岛素抵抗综合征的其他组成特征，包括糖耐量和胰岛素抵抗的两项替代指标（空腹胰岛素浓度和HOMA测量值），尽管与空腹甘油三酯浓度密切相关，但与餐后甘油三酯反应无关。当前吸烟习惯、长期饮酒和出生体重也与餐后甘油三酯反应改变无关。总之，这些结果表明，尽管胰岛素抵抗综合征的组成特征与空腹甘油三酯浓度升高相关，但其中许多特征，包括胰岛素敏感性的两项替代指标，与餐后甘油三酯反应过度无关。
