Lo S F, Chiang B L, Hsieh K H
Department of Pediatrics, En Chu Kong Hospital, San-Hsia, Taipei Hsien, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1997 Sep-Oct;38(5):375-80.
With advances in technology, several in vitro screening tests such as MAST and CAP system have been used for analyzing the allergens involved in allergic diseases such as bronchial asthma (BA), allergic rhinitis (AR), atopic dermatitis (AD) and urticaria. In this study, CAP system (Pharmacia, Sweden) was used to screen the prevalence of allergens responsible for these atopic diseases. A total of 392 children were enrolled in this study retrospectively, all these atopic children visited the allergy clinic of the Department of Pediatrics, National Taiwan University Hospital during the period March 1995 and August 1995. Our results showed: (1) Among these 392 allergic children, included 82 BA, 70 AR, 22 AD, 156 BA + AR. 8 BA + AD, 12 AR + AD, and 42 AD + AR + AD: (2) House dust mites (Dermatophagoides pteronyssinus: D. p and Dermatophagoides farinae: D. f) are the most common allergens triggering atopic disease in the Taiwan area. (3) Total IgE level is the highest in three combined allergic disease (BA + AR + AD) [2179.9 +/- 504.2KU/L] and lowest in single disease (AR) [503.1 +/- 84.8 KU/L]. Mite-specific IgE (D. p + D. f-specific IgE) concentration is also the highest in three combined disease (BA + AR + AD) [499.1 +/- 86.0KU/L] and lowest in AR [159.5 +/- 47.5 KU/L], (4) elevated specific IgE antibody to egg white and milk were found in 68.4% and 47.4% of patients with AD and/or urticaria. In conclusion, these data suggest that house dust mites, are the most important allergens in respiratory allergy as well as in atopic dermatitis, while food allergens play relatively important roles only in skin allergy. Furthermore, the highest IgE level was noted in children with combined allergic diseases.
随着技术的进步，多种体外筛查试验如MAST和CAP系统已被用于分析涉及支气管哮喘（BA）、过敏性鼻炎（AR）、特应性皮炎（AD）和荨麻疹等过敏性疾病的过敏原。在本研究中，使用CAP系统（瑞典法玛西亚公司）筛查这些特应性疾病相关过敏原的流行情况。本研究共回顾性纳入392名儿童，所有这些特应性儿童均于1995年3月至1995年8月期间就诊于台湾大学医院儿科过敏门诊。我们的结果显示：（1）在这392名过敏儿童中，包括82例BA、70例AR、22例AD、156例BA + AR、8例BA + AD、12例AR + AD以及42例AD + AR + AD；（2）屋尘螨（粉尘螨：D. p和户尘螨：D. f）是台湾地区引发特应性疾病最常见的过敏原；（3）总IgE水平在三种合并过敏性疾病（BA + AR + AD）中最高[2179.9±504.2KU/L]，在单一疾病（AR）中最低[503.1±84.8 KU/L]。螨特异性IgE（D. p + D. f特异性IgE）浓度在三种合并疾病（BA + AR + AD）中也最高[499.1±86.0KU/L]，在AR中最低[159.5±47.5 KU/L]；（4）在68.4%的AD和/或荨麻疹患者中发现蛋清和牛奶特异性IgE抗体升高。总之，这些数据表明，屋尘螨是呼吸道过敏以及特应性皮炎中最重要的过敏原，而食物过敏原仅在皮肤过敏中起相对重要的作用。此外，合并过敏性疾病的儿童中IgE水平最高。
