Hokibara S, Takamoto M, Tominaga A, Takatsu K, Sugane K
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
J Parasitol. 1997 Dec;83(6):1186-9.
In order to study the role of eosinophils in the host defense against Trichinella spiralis infection, worm recovery after infection with T. spiralis was compared between interleukin-5 transgenic (IL-5 Tg) mice with a constant high level of peripheral eosinophils and nontransgenic C3H/HeN mice. No significant difference in the recovery of muscle larvae or adult worms in the small intestine, fecundity of female adult worms, or infectivity of newborn larvae was observed between nonimmunized C3H/HeN and IL-5 Tg mice or C3H/HeN and IL-5 Tg mice immunized with somatic antigen of T. spiralis. However, a significant difference was observed in the fecundity of female adult worms and recovery of muscle larvae between nonimmunized and immunized IL-5 Tg mice or C3H/HeN mice. These results demonstrate that having more eosinophils does not improve immunity against the various aspects of T. spiralis infection.
为了研究嗜酸性粒细胞在宿主抵御旋毛虫感染中的作用，将外周嗜酸性粒细胞水平持续较高的白细胞介素-5转基因（IL-5 Tg）小鼠与非转基因C3H/HeN小鼠进行比较，观察感染旋毛虫后虫体的恢复情况。在未免疫的C3H/HeN小鼠与IL-5 Tg小鼠之间，或用旋毛虫体抗原免疫的C3H/HeN小鼠与IL-5 Tg小鼠之间，未观察到小肠内肌幼虫或成虫的恢复、雌虫的繁殖力或新生幼虫的感染力有显著差异。然而，在未免疫和免疫的IL-5 Tg小鼠或C3H/HeN小鼠之间，观察到雌虫繁殖力和肌幼虫恢复情况存在显著差异。这些结果表明，拥有更多嗜酸性粒细胞并不能提高对旋毛虫感染各个方面的免疫力。
