Marchesi C, Chiodera P, Ampollini P, Volpi R, Coiro V
Institute of Clinical Psychiatry, University of Parma, Italy.
Psychiatry Res. 1997 Oct 10;72(3):187-94. doi: 10.1016/s0165-1781(97)00101-7.
The circadian secretion of beta-endorphin, adrenocorticotropic hormone (ACTH), and cortisol was evaluated in 14 non-cirrhotic alcoholic men after 7 and 28 days of abstinence and in 12 sex- and age-matched normal subjects. A significant decrease in plasma levels of beta-endorphin, reduced ACTH levels, and increased cortisol levels were observed in samples taken at 08.00 h, 12.00 h, 18.00 h, and 23.00 h both after 7 and 28 days of abstinence. These data suggest the presence of a strong negative feedback on pro-opiomelanocortin synthesis by cortisol hypersecretion in abstinent alcoholics, which might be due to long-term stimulation of adrenal function by alcohol. The decreased plasma beta-endorphin levels might predispose to relapse in alcohol abuse.
对14名非肝硬化酒精性男性在戒酒7天和28天后以及12名年龄和性别匹配的正常受试者的β-内啡肽、促肾上腺皮质激素（ACTH）和皮质醇的昼夜分泌情况进行了评估。在戒酒7天和28天后，于08:00、12:00、18:00和23:00采集的样本中，观察到β-内啡肽血浆水平显著降低、ACTH水平降低以及皮质醇水平升高。这些数据表明，戒酒的酗酒者中皮质醇分泌过多对阿片促黑激素皮质素原合成存在强烈的负反馈，这可能是由于酒精对肾上腺功能的长期刺激所致。血浆β-内啡肽水平降低可能易导致酒精滥用复发。
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