ABO和Rh血型对免疫性血小板减少性紫癜（ITP）患儿静脉注射免疫球蛋白（IVIG）反应的影响。

The effect of ABO and Rh blood type on the response to intravenous immune globulin (IVIG) in children with immune thrombocytopenic purpura (ITP).

作者信息

Sturgill M G, Nagabandi S R, Drachtman R A, Ettinger A G, Rubin J, Ettinger L J

机构信息

Division of Pediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, USA.

出版信息

J Pediatr Hematol Oncol. 1997 Nov-Dec;19(6):523-5. doi: 10.1097/00043426-199711000-00006.

DOI:10.1097/00043426-199711000-00006

PMID:9407938

Abstract

PURPOSE

Immune thrombocytopenic purpura (ITP) is a common childhood illness characterized by thrombocytopenia secondary to shortened platelet survival. Medical therapy includes corticosteroids, intravenous immune globulin (IVIG), and IV Rho (D) immunoglobulin (anti-D). Individuals with Rh-negative blood generally do not respond to treatment with anti-D, but little information is currently available regarding the potential relationship between blood type and response to IVIG. This study was designed to characterize the relationship between ABO and Rh blood type and the response to IVIG in children and adolescents with newly diagnosed ITP.

PATIENTS AND METHODS

A retrospective chart review was performed for 52 children and adolescents with newly diagnosed ITP initially treated with IVIG by the Division of Pediatric Hematology-Oncology at Robert Wood Johnson University Hospital in New Brunswick, New Jersey.

RESULTS

There were no significant differences in response rate or clinical outcome by ABO blood group or Rh type in children with ITP who received IVIG monotherapy as their initial treatment.

CONCLUSIONS

ABO blood group and Rh type do not appear to be prognostic factors when IVIG monotherapy is the initial treatment for childhood ITP.

摘要

目的

免疫性血小板减少性紫癜（ITP）是一种常见的儿童疾病，其特征为血小板生存时间缩短继发血小板减少。医学治疗包括使用皮质类固醇、静脉注射免疫球蛋白（IVIG）以及静脉注射Rho（D）免疫球蛋白（抗-D）。Rh阴性血型的个体通常对抗-D治疗无反应，但目前关于血型与IVIG反应之间的潜在关系的信息较少。本研究旨在描述新诊断ITP的儿童和青少年中ABO和Rh血型与IVIG反应之间的关系。