Lindgren M, Johansson M, Sandström J, Jonsson Y, Bergenheim A T, Henriksson R
Department of Oncology, Umeå University, Sweden.
Acta Oncol. 1997;36(6):615-8. doi: 10.3109/02841869709001324.
Neovascularisation and migration of tumour cells are two features of highly malignant glioma. Vascular endothelial growth factor (VEGF) and tissue plasminogen activator (tPA) seem to be of importance in the process of malignancy. In the present study a topographical co-expression of tPA mRNA and VEGF mRNA (VEGF121 and VEGF165 isoforms) was demonstrated in the tumour edge of a rat malignant glioma, using in situ hybridisation. No signs of co-expression was seen in the normal brain tissue. In the normal brain the forms of VEGF mainly expressed were VEGF121, VEGF165, and VEGF189. Further studies are required to show whether VEGF and tPA are produced by the same tumour cells and to elucidate the role of this co-expression.
肿瘤细胞的新生血管形成和迁移是高度恶性胶质瘤的两个特征。血管内皮生长因子（VEGF）和组织型纤溶酶原激活物（tPA）在恶性肿瘤形成过程中似乎起着重要作用。在本研究中，通过原位杂交技术证实在大鼠恶性胶质瘤的肿瘤边缘tPA mRNA与VEGF mRNA（VEGF121和VEGF165亚型）存在局部共表达。在正常脑组织中未见共表达迹象。在正常脑组织中主要表达的VEGF形式为VEGF121、VEGF165和VEGF189。需要进一步研究以确定VEGF和tPA是否由相同的肿瘤细胞产生，并阐明这种共表达的作用。
