White H S, Wolf H H, Woodhead J H, Kupferberg H J
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
Adv Neurol. 1998;76:29-39.
The procedures employed by the ASP provide detailed information pertaining to the anticonvulsant profile of new candidate substances. In addition, the results obtained from tolerance and liver microsomal studies furnish critical information for predicting whether tolerance and/or serious drug-drug interactions are likely to develop following long-term administration of a candidate substance. Finally, in vitro mechanism-of-action studies supply preliminary information regarding the site of action of promising new anticonvulsant drugs. It is anticipated that the testing protocol outlined above will identify safer and mechanistically novel substances to enhance significantly the quality of life of those epilepsy patients still suffering from uncontrolled seizure disorders and/or experiencing significant adverse drug effects.
抗癫痫筛选程序（ASP）所采用的方法提供了与新候选物质抗惊厥特性相关的详细信息。此外，耐受性和肝脏微粒体研究所得结果为预测长期服用候选物质后是否可能产生耐受性和/或严重药物相互作用提供了关键信息。最后，体外作用机制研究提供了有关有前景的新型抗癫痫药物作用位点的初步信息。预计上述测试方案将识别出更安全且作用机制新颖的物质，从而显著提高那些仍患有无法控制的癫痫发作疾病和/或经历显著药物不良反应的癫痫患者的生活质量。
