对雄性大鼠生殖器官中睾酮向5α-二氢睾酮转化的抑制作用。

The inhibition of the conversion of testosterone into 5alpha-dihydrotestosterone in the reproductive organs of the male rat.

作者信息

Saksena S K, Lau I F, Chang M C

出版信息

Steroids. 1976 Jun;27(6):751-7. doi: 10.1016/0039-128x(76)90135-5.

Abstract

The inhibition of testosterone 5alpha-reductase activity by 3-oxo-4-androstene-17beta-carboxylic acid in the male reproductive organs of the rat was demonstrated in vitro. The medium for incubation of caput epididymis showed the highest concentration of 5alpha-dihydrotestosterone (5alpha-DHT) whereas the highest concentration of testosterone (T) was recorded in medium for incubation of decapsulated testis after two hours of incubation. The 3-oxo-4-androstene-17beta-carboxylic acid (1.58 X 10(-5)M) inhibited the conversion of T to 5alpha-DHT in all the organs tested (testis, caput and cauda epididymis and ventral prostate) under identical incubation conditions.

摘要

体外实验证明，3-氧代-4-雄烯-17β-羧酸可抑制大鼠雄性生殖器官中睾酮5α-还原酶的活性。附睾头孵育培养基中5α-双氢睾酮（5α-DHT）的浓度最高，而去被膜睾丸孵育两小时后的培养基中睾酮（T）的浓度最高。在相同孵育条件下，3-氧代-4-雄烯-17β-羧酸（1.58×10⁻⁵M）可抑制所测试的所有器官（睾丸、附睾头和附睾尾以及腹侧前列腺）中T向5α-DHT的转化。