McCarthy P L, Dolan T F
Am J Dis Child. 1976 Aug;130(8):849-51. doi: 10.1001/archpedi.1976.02120090059010.
In an eight-year period, 100 children were seen in a pediatric emergency room with a temperature of 41.1 C or higher, hereafter called hyperpyrexia. There was a significantly greater occurrence of bacterial meningitis in the hyperpyrexia group, compared to a group of 264 children with temperatures of 40.5 to 41.0 C. Bacteremia and seizures were also more common. Children with hyperpyrexia require careful evaluation, especially of the central nervous system.