Messer H D, Litvinoff J
Arch Neurol. 1976 Aug;33(8):571-6. doi: 10.1001/archneur.1976.00500080049007.
Pyogenic osteomyelitis of the cervical spine was successfully treated without bone grafting in 11 of 12 patients. Staphylococcus aureus was the most common organism. Four of the patients were heroin addicts, and six others had received parenteral injections under medical supervision. The patients were immobilized promptly, and after diagnostic procedures, cultures, and drainage when appropriate, they were treated with antibiotics, which led to spontaneous fusion in the 11 who survived. In the preantibiotic era, these infections frequently evolved into "epidural abscess", with resultant cord compression leading to permanent paralysis or death. Therefore, early differential diagnosis from tuberculosis or cancer is necessary. Today, with early diagnosis, immobilization, an anterior surgical approach when necessary, and the appropirate antibiotic, cure without neurological deficit should be the rule.
12例颈椎化脓性骨髓炎患者中有11例在未进行植骨的情况下得到成功治疗。金黄色葡萄球菌是最常见的病原体。其中4例患者为海洛因成瘾者,另外6例在医疗监督下接受过非肠道注射。患者均迅速制动,在完成诊断性检查、培养及必要的引流后,接受抗生素治疗,11例存活患者均实现了自发融合。在抗生素出现之前的时代,这些感染常常发展为“硬膜外脓肿”,导致脊髓受压,进而引起永久性瘫痪或死亡。因此,有必要早期与结核或癌症进行鉴别诊断。如今,通过早期诊断、制动、必要时采用前路手术入路以及使用合适的抗生素,应能实现无神经功能缺损的治愈。