Hashimoto Y, Terasaki T, Hara Y, Yonehara T, Uchino M
Department of Neurology, Kumamoto City Hospital.
Rinsho Shinkeigaku. 1997 Sep;37(9):851-3.
A 71-year-old man was admitted to our hospital because of headache and left hemiparesis. Brain CT scan showed hemorrhagic infarction of the right frontal lobe. Intravenous digital subtraction angiography revealed no occlusion of cerebral arteries. No arrhythmias were observed by the holter ECG. Transthoracic echocardiography showed no abnormalities. Anticoagulation therapy (heparin and warfarin) was started under the diagnosis of cerebral embolism without definite embolic source and there was no recurrence during following four years. Transesophageal echocardiography showed an atrial septal aneurysm (ASA) without patent foramen ovale. A potential cause of cerebral embolism due to atrial septal aneurysm is paradoxical embolization through an interatrial shunt (patent foramen ovale). It was speculated that ASA was a direct source of thrombus formation in this case (lone ASA). Transesophageal echocardiography should be performed to find atrial septal aneurysm in patients with cryptogenic stroke, especially embolic stroke without definite embolic sources.
一名71岁男性因头痛和左侧偏瘫入住我院。脑部CT扫描显示右额叶出血性梗死。静脉数字减影血管造影显示脑动脉无闭塞。动态心电图未观察到心律失常。经胸超声心动图未显示异常。在诊断为无明确栓子来源的脑栓塞后开始抗凝治疗(肝素和华法林),在随后的四年中未复发。经食管超声心动图显示房间隔瘤(ASA),无卵圆孔未闭。房间隔瘤导致脑栓塞的一个潜在原因是通过心房分流(卵圆孔未闭)的反常栓塞。推测在该病例中(孤立性ASA)ASA是血栓形成的直接来源。对于不明原因卒中患者,尤其是无明确栓子来源的栓塞性卒中患者,应进行经食管超声心动图检查以发现房间隔瘤。