异基因骨髓移植后复发为粒细胞肉瘤（绿色瘤）的髓系白血病和骨髓增生异常综合征

Myeloid leukemia and myelodysplastic syndrome relapsing as granulocytic sarcoma (chloroma) after allogeneic bone marrow transplantation.

作者信息

Szomor A, Passweg J R, Tichelli A, Hoffmann T, Speck B, Gratwohl A

机构信息

Department of Internal Medicine, Basel University Hospital, Switzerland.

出版信息

Ann Hematol. 1997 Nov-Dec;75(5-6):239-41. doi: 10.1007/s002770050350.

DOI:10.1007/s002770050350

PMID:9433383

Abstract

Of 229 consecutive patients receiving allogeneic blood or bone marrow stem cell transplants for acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndrome between 1974 and 1996, 52 patients relapsed. The original tumor recurred as granulocytic sarcoma (chloroma) in three patients (1.3%). Chloroma was found in the ovary in two patients and in the central nervous system in one patient. None of these three patients had experienced > or = grade II acute or more than limited chronic graft-versus-host disease. The intervals between transplantation and recurrence with chloroma were 2, 6, and 13 years. Two patients received a second transplant, and all three died of treatment sequelae.

摘要

在1974年至1996年间接受异基因血液或骨髓干细胞移植治疗急性髓细胞白血病、慢性髓细胞白血病或骨髓增生异常综合征的229例连续患者中，有52例复发。3例患者（1.3%）原肿瘤复发为粒细胞肉瘤（绿色瘤）。绿色瘤在2例患者的卵巢中发现，1例患者在中枢神经系统中发现。这3例患者均未经历≥II级急性或超过局限性慢性移植物抗宿主病。移植与绿色瘤复发之间的间隔时间分别为2年、6年和13年。2例患者接受了第二次移植，3例患者均死于治疗后遗症。