[口服耐受在类风湿关节炎及其他自身免疫性疾病治疗中的应用]
[Oral tolerance in the treatment of rheumatoid arthritis and other autoimmune diseases].
作者信息
Torigoe D Y, Yoshinari N H
机构信息
Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo.
出版信息
Rev Hosp Clin Fac Med Sao Paulo. 1997 Mar-Apr;52(2):96-100.
PMID:9435403
Abstract
Oral administration of antigen has been recognized as a form of inducing antigen-specific unresponsiveness. Studies in animal models of autoimmune diseases have shown the effectiveness of such an approach. Recently, three clinical trials have suggested that oral tolerance can be useful in human disease. In this review, we address the mechanisms underlying this system and the role of oral tolerance in the treatment of human autoimmune disease.
摘要
口服抗原已被公认为是诱导抗原特异性无反应性的一种形式。在自身免疫性疾病动物模型中的研究表明了这种方法的有效性。最近，三项临床试验表明口服耐受在人类疾病中可能有用。在这篇综述中，我们阐述了该系统的潜在机制以及口服耐受在人类自身免疫性疾病治疗中的作用。
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