垂体腺苷酸环化酶激活肽和血管活性肠肽对未成熟及成年大鼠睾丸功能的局部作用

Local effect of PACAP and VIP on testicular function in immature and adult rats.

作者信息

Csaba Z, Csernus V, Gerendai I

机构信息

Department of Human Morphology and Developmental Biology, Semmelweis University of Medicine, Budapest, Hungary.

出版信息

Peptides. 1997;18(10):1561-7. doi: 10.1016/s0196-9781(97)00243-x.

DOI:10.1016/s0196-9781(97)00243-x

PMID:9437717

Abstract

PACAP, VIP, anti-PACAP and anti-VIP antisera were injected intratesticularly. In 9-day-old hemicastrated rats PACAP or VIP decreased basal testosterone secretion. In 22-day-old hemicastrates VIP but not PACAP reduced compensatory testicular hypertrophy, however, neither PACAP nor VIP altered steroidogenesis. Anti-VIP antiserum to this age group increased testosterone production and enhanced compensatory testicular hypertrophy. In adult hemicastrates neither the peptides nor the antisera influenced steroidogenesis. Neither in immatures nor in adults treatment of both testes with PACAP or VIP had any effect. Data indicate that both PACAP and VIP might exert a local action on testicular steroidogenesis, on compensatory testicular hypertrophy, and these effects are age-dependent.

摘要

将垂体腺苷酸环化酶激活肽（PACAP）、血管活性肠肽（VIP）、抗PACAP和抗VIP抗血清进行睾丸内注射。在9日龄半阉割大鼠中，PACAP或VIP降低了基础睾酮分泌。在22日龄半阉割大鼠中，VIP而非PACAP减少了代偿性睾丸肥大，然而，PACAP和VIP均未改变类固醇生成。针对该年龄组的抗VIP抗血清增加了睾酮生成并增强了代偿性睾丸肥大。在成年半阉割大鼠中，肽类和抗血清均未影响类固醇生成。无论是在未成熟大鼠还是成年大鼠中，用PACAP或VIP处理双侧睾丸均无任何作用。数据表明，PACAP和VIP可能对睾丸类固醇生成及代偿性睾丸肥大发挥局部作用，且这些作用具有年龄依赖性。