Fojt E, Ekelund L G, Hultman E
Pflugers Arch. 1976 Feb 24;361(3):287-96. doi: 10.1007/BF00587294.
In order to study the influence of physical exercise on liver function, experiments were performed in healthy volunteers subjected to controlled major physical effort. Blood samples obtained by catheterization of hepatic vein during exercise were analyzed for activities of LD (thermostabile and thermolabile isoenzymes), AlAT, SDH, ICD, AP and CPK, and these activities were compared with corresponding values in arterial blood samples taken simultaneously. Hepatic blood flow and oxygen saturation of hepatic venous blood were measured. Physical exercise resulted both in diminished hepatic blood flow and a fall in hepatic venous oxygen saturation. These changes were accompanied by release of liver specific enzymes, indicating that exhausting exercise may induce an "increased hepatocyte membrane permeability" in man.
为了研究体育锻炼对肝功能的影响，对进行可控大强度体力活动的健康志愿者进行了实验。在运动期间通过肝静脉插管采集的血样，分析了乳酸脱氢酶（热稳定和热不稳定同工酶）、谷丙转氨酶、山梨醇脱氢酶、异柠檬酸脱氢酶、碱性磷酸酶和肌酸磷酸激酶的活性，并将这些活性与同时采集的动脉血样中的相应值进行比较。测量了肝血流量和肝静脉血的氧饱和度。体育锻炼导致肝血流量减少和肝静脉血氧饱和度下降。这些变化伴随着肝脏特异性酶的释放，表明力竭运动可能会导致人体“肝细胞膜通透性增加”。
