局部应用丝裂霉素C治疗复发性结膜上皮肿瘤
Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C.
作者信息
Heigle T J, Stulting R D, Palay D A
机构信息
Bascom Palmer Eye Institute, Emory University, Atlanta, GA 30322, USA.
出版信息
Am J Ophthalmol. 1997 Sep;124(3):397-9. doi: 10.1016/s0002-9394(14)70834-7.
PURPOSE
To study the effect of topical mitomycin C on conjunctival squamous neoplasia.
METHODS
Three patients with recurrent conjunctival epithelial neoplasia were treated with topical mitomycin C 0.04%.
RESULTS
Six to 9 months after treatment, no patient had clinical evidence of tumor recurrence. Conjunctival biopsy in two patients and cytology in one patient showed no evidence of tumor 1 to 4 months after treatment. One patient required short-term treatment for corneal edema and epithelial toxicity.
CONCLUSION
Topical mitomycin C caused tumor regression without recurrence for 6 to 9 months after treatment.
目的
研究局部应用丝裂霉素C对结膜鳞状上皮瘤的作用。
方法
3例复发性结膜上皮瘤患者接受0.04%的局部丝裂霉素C治疗。
结果
治疗后6至9个月，无患者有肿瘤复发的临床证据。2例患者的结膜活检及1例患者的细胞学检查显示治疗后1至4个月无肿瘤迹象。1例患者因角膜水肿和上皮毒性需要短期治疗。
结论
局部应用丝裂霉素C可使肿瘤消退，治疗后6至9个月无复发。
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