White R N, Cobb M A, Brownlie S E, Pattison C W, Cumming D V, Jones D G, Williamson H A, Yacoub M H
Department of Small Animal Medicine and Surgery, Royal Veterinary College, University of London, Hatfield, Hertfordshire.
J Small Anim Pract. 1997 Dec;38(12):554-60. doi: 10.1111/j.1748-5827.1997.tb03317.x.
Skeletal muscle extra-aortic counterpulsation was performed in seven dogs with dilated cardiomyopathy. A left latissimus dorsi dynamic descending thoracic aortomyoplasty was used as the autologous counterpulsator. Pulse train stimulation in diastole was used to initiate contraction and fibre type transformation. Two of the dogs died within 48 hours of surgery. The device was successfully activated in the five remaining dogs, but in one individual it failed within 48 hours of activation. Serial echocardiographic examinations of dogs in which the device functioned successfully (n = 4) showed trends towards the decrease in the left ventricular systolic internal dimension, left ventricular diastolic internal dimension, E-point to septal separation and left atrial diameter in systole seven to 14 days following the procedure, although these changes failed to persist in the long-term. The results suggest that skeletal muscle for cardiac assistances such as extra-aortic muscle counterpulsation, might be a therapeutic option for dogs with cardiac failure due to dilated cardiomyopathy.
对七只患有扩张型心肌病的犬进行了骨骼肌主动脉外反搏。采用左背阔肌动态降胸主动脉成形术作为自体反搏器。在舒张期进行脉冲串刺激以引发收缩和纤维类型转变。其中两只犬在手术后48小时内死亡。其余五只犬的装置成功激活，但其中一只在激活后48小时内失效。对装置功能成功的犬（n = 4）进行的系列超声心动图检查显示，术后7至14天，左心室收缩内径、左心室舒张内径、E点至室间隔距离和收缩期左心房直径有减小趋势，尽管这些变化未能长期持续。结果表明，骨骼肌用于诸如主动脉外肌肉反搏等心脏辅助，可能是患有扩张型心肌病所致心力衰竭犬的一种治疗选择。
