剖析病原体在感染过程中的生物学特性。
Dissecting the biology of a pathogen during infection.
作者信息
Heithoff D M, Conner C P, Mahan M J
机构信息
Dept of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara 93106, USA.
出版信息
Trends Microbiol. 1997 Dec;5(12):509-13. doi: 10.1016/S0966-842X(97)01153-0.
PMID:9447664
Abstract
In vivo expression studies reveal many bacterial genes that contribute to the fitness of the organism in the context of host ecology. This collection of virulence genes defines the unique lifestyle of a pathogen during infection, pointing to the functions that dictate host specificity, tissue tropism and disease manifestation.
摘要
体内表达研究揭示了许多在宿主生态环境中有助于生物体适应性的细菌基因。这些毒力基因集合定义了病原体在感染期间独特的生存方式，指出了决定宿主特异性、组织嗜性和疾病表现的功能。
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