Rodriguez M M, Grossberg G T
Department of Psychiatry, St. Louis University School of Medicine, St. Louis, Missouri 63104, USA.
Clin Geriatr Med. 1998 Feb;14(1):177-89.
This article provides information on the effects of estrogen as a psychotherapeutic agent. Estrogen has a positive effect on several neurotransmitter systems that are assumed to be involved in regulation of affect, behavior, and cognition. Clinical studies suggest that an important cause of nonresponsiveness to antidepressants in postmenopausal women may be inadequate hormone replacement. Potential uses of estrogen as a mood stabilizer or mood enhancer also are described in this article. In the area of behavior, estrogen regulates aggressivity, sexual drive, impulsivity, and hostility. In terms of cognition, evidence suggests the importance of estrogen in the prevention and treatment of Alzheimer's-type dementia. At the end of the article, future research directions are discussed.
本文提供了有关雌激素作为一种心理治疗药物的作用的信息。雌激素对几个被认为参与情感、行为和认知调节的神经递质系统有积极作用。临床研究表明，绝经后女性对抗抑郁药无反应的一个重要原因可能是激素替代不足。本文还描述了雌激素作为情绪稳定剂或情绪增强剂的潜在用途。在行为方面，雌激素调节攻击性、性欲、冲动性和敌意。在认知方面，有证据表明雌激素在预防和治疗阿尔茨海默病型痴呆症方面具有重要作用。文章结尾讨论了未来的研究方向。
