[α2-肾上腺素能受体激动剂的最佳神经保护剂量对正常条件下及随后缺血时脑总血流量的影响]
[Effect of the optimal neuroprotective doses of alpha2-adrenoreceptor agonists on the total cerebral blood flow in the normal conditions and in subsequent ischemia].
作者信息
Kulinskiĭ V I, Medvedeva T N, Usov L A, Ekimov E N
机构信息
Irkutsk State Medical University, Russia.
出版信息
Eksp Klin Farmakol. 1997 Nov-Dec;60(6):7-9.
PMID:9460587
Abstract
Optimal neuroprotective doses of clonidine and guanobenz considerably reduce the total cerebral blood flow and reduce or do not change arterial pressure. In occlusion of the carotid arteries the alpha 2-agonists fail to reduce the degree of cerebral ischemia and hypotension. The neuroprotective effect of alpha 2-adrenoceptor-agonists is not a result of cerebral blood flow improvement.
摘要
可乐定和胍那苄的最佳神经保护剂量可显著降低脑血流量总量，并降低或不改变动脉血压。在颈动脉闭塞时，α2激动剂不能降低脑缺血程度和低血压。α2肾上腺素能受体激动剂的神经保护作用并非改善脑血流量的结果。
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