正常男性体内人促卵泡生成素（hFSH）和人促黄体生成素（hLH）的输注。I. 人促卵泡刺激素的动力学

Infusions of hFSH and hLH in normal men. I. Kinetics of human follicle stimulating hormone.

作者信息

Kjeld J M, Harsoulis P, Kuku S F, Marshall J C, Kaufman B, Fraser T R

出版信息

Acta Endocrinol (Copenh). 1976 Feb;81(2):225-33. doi: 10.1530/acta.0.0810225.

DOI:10.1530/acta.0.0810225

Abstract

Serial serum assays of immunoreactive FSH before, during and after a 4 h intravenous infusion of human follicle stimulating hormone (hFSH) in five healthy men revealed two disappearance rate constants with corresponding mean half-lives of 2.9 and 50.6 h. The mean distribution spaces calculated for the fast and slow component were 4.36 1 and 75.9 1 respectively. The average value for the metabolic clearance rate was 17.2 ml/min and for the endogenous production rate 50.9 mU/min. Two of the subjects had human luteinizing hormone (hLH) added in the infusions without the FSH kinetics changing.

摘要

对5名健康男性在静脉输注人卵泡刺激素（hFSH）4小时的前、中、后进行免疫反应性FSH的系列血清检测，结果显示有两个消失速率常数，相应的平均半衰期分别为2.9小时和50.6小时。快速和慢速成分的平均分布容积分别计算为4.36升和75.9升。代谢清除率的平均值为17.2毫升/分钟，内源性产生率为50.9毫国际单位/分钟。其中两名受试者在输注中加入了人促黄体生成素（hLH），而FSH的动力学未发生改变。