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Living skin equivalents are the combination of the bioengineering and tissue-transplantation sciences. Their uses have applications in aiding wound healing for ulcerations caused by thermal injury, diabetic neuropathy, venous hypertension, and pressure. Products can be divided into keratinocyte sheets, dermal replacements, or composite material. Past and current studies give the Food and Drug Administration and health care providers valuable data relating to these products' efficacy in the wound healing arena.