Palefsky J M, Holly E A, Ralston M L, Jay N
Department of Laboratory Medicine, University of California, San Francisco, 94143, USA.
J Infect Dis. 1998 Feb;177(2):361-7. doi: 10.1086/514194.
One of the groups at highest risk of anal cancer is homosexual and bisexual men. Like cervical cancer, anal cancer is associated with human papillomavirus (HPV) infection. Anal HPV infection was characterized in a study of 346 human immunodeficiency virus (HIV)-positive and 262 HIV-negative homosexual and bisexual men. Anal HPV DNA was detected in 93% of HIV-positive and 61% of HIV-negative men by polymerase chain reaction. The spectrum of HPV types was similar in HIV-positive and HIV-negative men, with HPV-16 the most common type. Infection with multiple HPV types was found in 73% of HIV-positive and 23% of HIV-negative men. Among HIV-positive men who were positive by hybrid capture for group B HPV types (16/18/31/33/35/39/45/51/52/56/58) or group A types (6/11/42/43/44), lower CD4 cell levels were associated with higher levels of group B DNA (P = .004) but not group A DNA. These data suggest increased replication of the more oncogenic HPV types with more advanced immunosuppression.
肛门癌风险最高的群体之一是男同性恋者和双性恋男性。与宫颈癌一样，肛门癌与人乳头瘤病毒（HPV）感染有关。一项针对346名人类免疫缺陷病毒（HIV）阳性和262名HIV阴性的男同性恋者和双性恋男性的研究对肛门HPV感染进行了特征分析。通过聚合酶链反应在93%的HIV阳性男性和61%的HIV阴性男性中检测到肛门HPV DNA。HIV阳性和HIV阴性男性的HPV类型谱相似，HPV-16是最常见的类型。在73%的HIV阳性男性和23%的HIV阴性男性中发现了多种HPV类型感染。在通过杂交捕获检测B组HPV类型（16/18/31/33/35/39/45/51/52/56/58）或A组类型（6/11/42/43/44）呈阳性的HIV阳性男性中，较低的CD4细胞水平与较高的B组DNA水平相关（P = 0.004），但与A组DNA无关。这些数据表明，随着免疫抑制的加重，更具致癌性的HPV类型的复制增加。
