Ikeda N, Takayanagi K, Takeuchi A, Nara Y, Miyahara H
School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
Methods Inf Med. 1997 Dec;36(4-5):286-9.
A problem of identifying the phase response curve of the myocardial pacemaker was investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization method of a genetic algorithm and a local optimization technique was employed to obtain a solution of the model fitting. The method was applied to two categories of arrhythmias, ventricular parasystole and high-degree AV block. The present study offered a new insight into the mechanism of cardiac arrhythmias.
利用一个简单的心律失常动态系统模型,研究了识别心肌起搏器相位响应曲线的问题。采用遗传算法和局部优化技术相结合的混合优化方法来获得模型拟合的解。该方法应用于两类心律失常,即室性并行心律和高度房室传导阻滞。本研究为心律失常的机制提供了新的见解。