Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A, Gebel J, Mills D, Minneci L, Shukla R
Department of Neurology, University of Cincinnati Medical Center, Ohio 45267-0525, USA.
Stroke. 1998 Feb;29(2):415-21. doi: 10.1161/01.str.29.2.415.
The Greater Cincinnati/Northern Kentucky Stroke Study was designed to be the first large, population-based metropolitan study of temporal trends in stroke incidence rates and outcome within a biracial population.
We are identifying all hospitalized and autopsied cases of stroke and transient ischemic attack (TIA) among the 1.3 million inhabitants of a five-county region of Greater Cincinnati/Northern Kentucky for the period 7/1/93-6/30/94. We have already prospectively monitored for out-of-hospital stroke and TIAs for this same time period at 128 screening sites, including a random sample of all primary care physicians and nursing homes in the region. We have already identified all hospitalized and autopsied cases of stroke and TIA among blacks for 1/1/93-6/30/93 and report preliminary incidence rates for this 6-month period.
The overall incidence rate for all first-ever hospitalized or autopsied stroke (excluding TIAs) among blacks in the Greater Cincinnati region was 288 per 100000 (95% CI, 250 to 325, age- and sex-adjusted to 1990 US population). The overall incidence rate for first-ever and recurrent stroke (excluding TIAs) was 411 per 100000 (95% CI, 366 to 456). By comparison, the overall incidence rate of first-ever stroke among whites in Rochester, Minn, during the period 1985-1989 was 179 per 100000 (95% CI, 164 to 194, age- and-sex adjusted to 1990 US population). The incidence rates among blacks in Greater Cincinnati were substantially greater than the rates among whites in Rochester, Minn, for all age categories except ages 75 and older, for which the rates were similar.
We conservatively estimate that 731100 first-ever or recurrent strokes occurred in the United States during 1996. Studies of first-ever as well as total stroke among biracial and representative populations are critical for understanding temporal trends in the incidence rate and the burden of stroke in the US population.
大辛辛那提/北肯塔基卒中研究旨在成为首个基于大都市人群的关于不同种族卒中发病率和转归时间趋势的大型研究。
我们正在确定1993年7月1日至1994年6月30日期间大辛辛那提/北肯塔基五县地区130万居民中所有住院和尸检的卒中和短暂性脑缺血发作（TIA）病例。同期，我们已在128个筛查点对院外卒中和TIA进行前瞻性监测，其中包括该地区所有初级保健医生和疗养院的随机样本。我们已确定1993年1月1日至1993年6月30日期间黑人中所有住院和尸检的卒中和TIA病例，并报告了这6个月期间的初步发病率。
大辛辛那提地区黑人中所有首次住院或尸检的卒中（不包括TIA）总体发病率为每100000人288例（95%CI，250至325，年龄和性别调整为1990年美国人口）。首次和复发性卒中（不包括TIA）的总体发病率为每100000人411例（95%CI，366至456）。相比之下，1985 - 1989年期间明尼苏达州罗切斯特市白人中首次卒中的总体发病率为每100000人179例（95%CI，164至194，年龄和性别调整为1990年美国人口）。除75岁及以上年龄组发病率相似外，大辛辛那提地区黑人的发病率在所有年龄组均显著高于明尼苏达州罗切斯特市白人的发病率。
我们保守估计，1996年美国发生了731100例首次或复发性卒中。对不同种族和代表性人群中的首次卒中和总卒中进行研究，对于了解美国人群中卒中发病率的时间趋势和卒中负担至关重要。
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