粟酒裂殖酵母中核分裂起始与细胞分裂起始的协调：突变的遗传相互作用
Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe: genetic interactions of mutations.
作者信息
Grallert A, Grallert B, Ribar B, Sipiczki M
机构信息
Department of Genetics, University of Debrecen, Hungary.
出版信息
J Bacteriol. 1998 Feb;180(4):892-900. doi: 10.1128/JB.180.4.892-900.1998.
Abstract
sep1+ encodes a Schizosaccharomyces pombe homolog of the HNF-3/forkhead family of the tissue-specific and developmental gene regulators identified in higher eukaryotes. Its mutant allele sep1-1 causes a defect in cytokinesis and confers a mycelial morphology. Here we report on genetic interactions of sep1-1 with the M-phase initiation mutations wee1-, cdc2-1w, and cdc25-22. The double mutants sep1-1 wee1- and sep1-1 cdc2-1w form dikaryon cells at high frequency, which is due to nuclear division in the absence of cell division. The dikaryosis is reversible and suppressible by cdc25-22. We propose that the genes wee1+, cdc2+, cdc25+, and sep1+ form a regulatory link between the initiation of mitosis and the initiation of cell division.
摘要
sep1+编码粟酒裂殖酵母中HNF-3/叉头家族的一个同源物，该家族是在高等真核生物中发现的组织特异性和发育基因调节因子。其突变等位基因sep1-1会导致胞质分裂缺陷并赋予菌丝形态。在此，我们报告sep1-1与M期起始突变wee1-、cdc2-1w和cdc25-22之间的遗传相互作用。双突变体sep1-1 wee1-和sep1-1 cdc2-1w高频形成双核细胞，这是由于在没有细胞分裂的情况下进行核分裂所致。双核化是可逆的，并且可被cdc25-22抑制。我们提出，基因wee1+、cdc2+、cdc25+和sep1+在有丝分裂起始和细胞分裂起始之间形成了一个调节联系。
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