Davis-Fleischer K M, Besner G E
Department of Surgery, Children's Hospital and The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA.
Front Biosci. 1998 Mar 1;3:d288-99. doi: 10.2741/a241.
Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated signaling, and role in several important biological systems.
肝素结合表皮生长因子样生长因子（HB-EGF）是一种22 kDa的O-糖基化蛋白，对成纤维细胞、平滑肌细胞（SMC）和上皮细胞具有促有丝分裂作用。本综述描述了HB-EGF的一级结构及其加工过程。还讨论了小鼠和人HB-EGF基因的结构。最后，本综述总结了HB-EGF的表达模式、受体介导的信号传导及其在几个重要生物系统中的作用。
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