Liu I S, Kusumi I, Ulpian C, Tallerico T, Seeman P
Department of Pharmacology, Faculty of Medicine, University of Toronto, Medical Science Building, 8 Taddle Creek Road, Toronto, Ontario M5S 1A8, Canada.
Brain Res Mol Brain Res. 1998 Jan;53(1-2):98-103. doi: 10.1016/s0169-328x(97)00283-0.
During a search for new G-protein-linked receptors for dopamine and serotonin, we found a serotonin-4 receptor-like pseudogene. This receptor-like pseudogene is intronless, contains an in-frame stop codon following transmembrane-3, and has two one-nucleotide insertions between transmembrane-5 and -6 regions which alter the reading frame. The predicted amino acid sequence of the human pseudogene is about 35% identical with that of the rat serotonin-4 receptor.
在寻找多巴胺和5-羟色胺新的G蛋白偶联受体的过程中，我们发现了一个类5-羟色胺-4受体假基因。这个类受体假基因无内含子，在跨膜区3之后含有一个符合读框的终止密码子，并且在跨膜区5和6之间有两个单核苷酸插入，这改变了读框。人类假基因的预测氨基酸序列与大鼠5-羟色胺-4受体的预测氨基酸序列约有35%的同源性。
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