McBride J M, Kraemer W J, Triplett-McBride T, Sebastianelli W
Department of Kinesiology, Noll Physiological Research Center, The Pennsylvania State University, University Park 16802, USA.
Med Sci Sports Exerc. 1998 Jan;30(1):67-72. doi: 10.1097/00005768-199801000-00010.
The purposes of this investigation were to see whether free radical production changed with high intensity resistance exercise and, secondly, to see whether vitamin E supplementation would have any effect on free radical formation or variables associated with muscle membrane disruption. Twelve recreationally weight-trained males were divided into two groups. The supplement group (S) received 1200 IUs of vitamin E once a day (3 x 400 IU x d[-1]) for a period of 2 wk. The placebo group (P) received cellulose-based placebo pills once a day for the same period of time. Creatine kinase activity was significantly elevated between preexercise and immediately postexercise, 6 h postexercise, and 24 h postexercise for both groups. The placebo group also had a significant increase in creatine kinase activity at 48 h postexercise. There was a significant difference in creatine kinase activity between the groups at 24 h after exercise. Plasma malondialdehyde significantly increased from preexercise levels for the P group at 6 and 24 h postexercise. Plasma malondialdehyde concentrations significantly increased in the S group between preexercise and immediately postexercise levels. This study indicates that high intensity resistance exercise increases free radical production and that vitamin E supplementation may decrease muscle membrane disruption.
本研究的目的，一是观察高强度抗阻运动后自由基生成是否发生变化；二是观察补充维生素E是否会对自由基形成或与肌膜破坏相关的变量产生影响。12名有休闲负重训练经验的男性被分为两组。补充组（S）每天服用1200国际单位的维生素E（3×400国际单位×天[-1]），持续2周。安慰剂组（P）在相同时间段内每天服用纤维素基安慰剂丸。两组在运动前、运动后即刻、运动后6小时和24小时，肌酸激酶活性均显著升高。安慰剂组在运动后48小时肌酸激酶活性也显著增加。运动后24小时，两组间肌酸激酶活性存在显著差异。安慰剂组在运动后6小时和24小时，血浆丙二醛水平较运动前显著升高。补充组在运动前和运动后即刻，血浆丙二醛浓度显著增加。本研究表明，高强度抗阻运动可增加自由基生成，补充维生素E可能会减少肌膜破坏。
