Jones H E, Li H, Balster R L
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0310, USA.
Pharmacol Biochem Behav. 1998 Feb;59(2):413-8. doi: 10.1016/s0091-3057(97)00452-8.
The discriminative stimulus properties of ibogaine were investigated in rats trained to discriminate phencyclidine (PCP; 2.0 mg/kg, I.P.) from saline under a two-lever fixed-ratio (FR) 32 schedule of food reinforcement. Ibogaine (5.6-17.6 mg/kg, I.P.) showed a complete lack of substitution. Ibogaine (0.5-4.0 mg/kg, I.M.) also failed to generalize in rhesus monkeys trained to discriminate PCP (0.1 mg/kg, I.M.) from sham injection. Lysergic acid diethylamide (LSD), tested as a reference compound, produced partial substitution for PCP in rats and occasioned little responding on the PCP-associated lever in monkeys. These results demonstrate important differences between the behavioral effects of PCP and other types of hallucinogenic drugs such as LSD and ibogaine and do not support the hypothesis that the affinity of ibogaine for the PCP site on N-methyl-D-aspartate (NMDA) receptors plays a major role in its acute behavioral effects.
在以食物强化的双杠杆固定比率（FR）32 程序下训练大鼠区分苯环利定（PCP；2.0 毫克/千克，腹腔注射）和生理盐水的实验中，对伊博格碱的辨别刺激特性进行了研究。伊博格碱（5.6 - 17.6 毫克/千克，腹腔注射）完全没有替代作用。在训练区分 PCP（0.1 毫克/千克，肌肉注射）和假注射的恒河猴中，伊博格碱（0.5 - 4.0 毫克/千克，肌肉注射）也未能产生泛化作用。作为参考化合物进行测试的麦角酸二乙酰胺（LSD），在大鼠中对 PCP 产生了部分替代作用，而在猴子中与 PCP 相关的杠杆上引起的反应很少。这些结果表明 PCP 与其他类型的致幻药物（如 LSD 和伊博格碱）的行为效应之间存在重要差异，并且不支持关于伊博格碱对 N - 甲基 - D - 天冬氨酸（NMDA）受体上 PCP 位点的亲和力在其急性行为效应中起主要作用的假设。
