Marcellino L R, Vinciguerra M, Marcellino M V, Sessa E
Istituto di III Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi La Sapienza, Roma.
G Chir. 1997 Oct;18(10):605-7.
Our group, thanks to the considerable help offered by prof. S. Fujimoto, Chief of the Immunologic Oncology Department of the Kochi Medical School (Japan), developed a method of "in vitro" activation of cytotoxic T lymphocytes (CTL), which are directed against tumour-specific antigens MHC-linked of the tumor cells. A protocol of specific immunotherapy based on the use of the CTL cells appropriately manipulated as therapeutic agents is our goal. The protocol recognizes five essential points: 1) retrieve and culture of tumor cells; 2) retrieve of T Lymphocytes; 3) induction of CTL cells; 4) assay of CTL activity; 5) reinfusion of the activated CTL cells to the patient.
我们的团队在日本高知医科大学免疫肿瘤学系主任藤本教授的大力帮助下，开发了一种“体外”激活细胞毒性T淋巴细胞（CTL）的方法，这些细胞毒性T淋巴细胞针对肿瘤细胞的肿瘤特异性抗原MHC相关抗原。我们的目标是制定一种基于将经过适当处理的CTL细胞用作治疗剂的特异性免疫治疗方案。该方案包括五个要点：1）肿瘤细胞的获取和培养；2）T淋巴细胞的获取；3）CTL细胞的诱导；4）CTL活性的检测；5）将活化的CTL细胞重新注入患者体内。
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