Chu N F, Rimm E B, Wang D J, Liou H S, Shieh S M
Department of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Int J Obes Relat Metab Disord. 1998 Jan;22(1):66-72. doi: 10.1038/sj.ijo.0800546.
To evaluate the association between anthropometric parameters and lipid levels among Taiwanese school children.
Using a probability-proportional-to size sampling and multi-stages sampling procedure, we sampled 1500 school children from 10 schools in Taipei city. Anthropometric parameters including body weight, body height, waist circumference, hip circumference and skinfolds were measured. Serum total cholesterol (CHOL), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A1 and B (ApoA1 and ApoB) were measured by standard methods, low density lipoprotein-cholesterol (LDL-C) and CHOL/HDL-C ratio were calculated by formula.
We included in our analyses 1366 children (681 boys and 685 girls) with a mean age of 13.3 y (from 12 to 16 y) and with valid anthropometric and biochemical parameters. The boys had higher body height (P < 0.001) and larger body weight (P < 0.05), waist circumference (P < 0.01) and waist/hip ratio (WHR, P < 0.001) than the girls. However, the girls had larger skinfolds than the boys. After adjusting for age, girls had higher total CHOL, TG, HDL-C, LDL-C, ApoA1 and ApoB concentrations than boys. In general, TG was positively associated with most anthropometric parameters (except body height); a similar negative association between HDL-C and anthropometric variables was noted. After controlling, for age, cigarette smoking, alcohol drinking and puberty development, shorter body height was the strongest predictor of total CHOL, LDL-C and ApoB concentrations among boys. Although body mass index (BMI) was a significant positive predictor (P < 0.01) of the CHOL/HDL-C ratio; skinfold measurements were the strongest anthropometric predictors of most lipid concentrations among boys. Among girls, we found WHR and BMI to be the strongest positive predictors of TG and ApoB level respectively (both P < 0.001), but skinfold measurements were best for predicting HDL-C, LDL-C, ApoA1 and the CHOL/HDL-C ratio.
From this large study of school-age children from Taiwan, we found anthropometric parameters, such as body height, BMI or WHR, are adequate predictors of blood lipid levels; however, skinfold measurements are generally more strongly associated with lipid levels in both genders.
评估台湾学童人体测量学参数与血脂水平之间的关联。
采用按规模大小概率抽样和多阶段抽样程序，从台北市10所学校抽取1500名学童。测量人体测量学参数，包括体重、身高、腰围、臀围和皮褶厚度。采用标准方法测量血清总胆固醇（CHOL）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1和B（ApoA1和ApoB），通过公式计算低密度脂蛋白胆固醇（LDL-C）和CHOL/HDL-C比值。
我们纳入分析的1366名儿童（681名男孩和685名女孩）平均年龄为13.3岁（12至16岁），且有有效的人体测量学和生化参数。男孩的身高（P<0.001）、体重（P<0.05）、腰围（P<0.01）和腰臀比（WHR，P<0.001）均高于女孩。然而，女孩的皮褶厚度比男孩大。在调整年龄后，女孩的总CHOL、TG、HDL-C、LDL-C、ApoA1和ApoB浓度高于男孩。总体而言，TG与大多数人体测量学参数呈正相关（身高除外）；HDL-C与人体测量学变量之间存在类似的负相关。在控制年龄、吸烟、饮酒和青春期发育后，身高较短是男孩总CHOL、LDL-C和ApoB浓度的最强预测因素。虽然体重指数（BMI）是CHOL/HDL-C比值的显著正预测因素（P<0.01）；皮褶测量是男孩中大多数血脂浓度的最强人体测量学预测因素。在女孩中，我们发现WHR和BMI分别是TG和ApoB水平的最强正预测因素（均P<0.001），但皮褶测量最适合预测HDL-C、LDL-C、ApoA1和CHOL/HDL-C比值。
通过对台湾学龄儿童的这项大型研究，我们发现人体测量学参数，如身高、BMI或WHR，是血脂水平的充分预测指标；然而，皮褶测量通常与两性的血脂水平关联更强。
