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[喉癌放疗后复发的挽救性治疗结果]

[Results of salvage treatment of carcinoma of the larynx recurring after radiotherapy].

作者信息

León X, Quer M, De Juan M, Vega M, Guedea F, Venegas M P, Burgués J

机构信息

Servicio de ORL, Hospital de la Sta, Creu i Sant Pau, Universitat Autònoma de Barcelona.

出版信息

Acta Otorrinolaringol Esp. 1997 Oct;48(7):537-43.

PMID:9489155
Abstract

An analysis is made of salvage treatments and their results after unsuccessful radiotherapy in 113 carcinomas of the larynx. A group of 27 patients (24%) was excluded from salvage treatment. In the remaining 86 patients (76%), radical surgical salvage treatment was tried: total laryngectomy (74 cases) or partial surgery (12 cases). Four of the 12 patients treated with partial surgery suffered a second local relapse, which was rescued by new surgery. Treatment was successful in 72% of the laryngectomized patients and in all those treated with partial surgery. Survival correlated with local (T) and regional (N) extension of the initial tumor, its location, and simultaneous regional relapse. In contrast, survival did not correlate with the time interval between end of radiotherapy and relapse, or with local tumoral extension in the resection piece in surgically treated cases (rpT).

摘要

对113例喉癌患者放疗失败后的挽救性治疗及其结果进行了分析。一组27例患者(24%)被排除在挽救性治疗之外。在其余86例患者(76%)中,尝试了根治性手术挽救治疗:全喉切除术(74例)或部分手术(12例)。接受部分手术治疗的12例患者中有4例出现了第二次局部复发,通过再次手术得以挽救。全喉切除患者中有72%的治疗成功,所有接受部分手术治疗的患者也均成功。生存率与初始肿瘤的局部(T)和区域(N)扩展、其位置以及同时出现的区域复发相关。相比之下,生存率与放疗结束至复发的时间间隔无关,也与手术治疗病例(rpT)切除标本中的局部肿瘤扩展无关。

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