Mizejewski G J, Dillon W R
Arch Immunol Ther Exp (Warsz). 1979;27(5):655-62.
Mice bearing the BW7756 hepatoma were passively immunized using rabbit antiserum to murine alpha-fetoprotein (AFP) administered in constant or increasing doses. Control tumor-bearing mice were inoculated with saline or nonimmune rabbit serum (NRS) (constant or increasing doses), or were left untreated. The tumor growth curves from mice receiving constant or increasing doses of anti-AFP or constant doses of NRS showed suppression of hepatoma growth; but in both groups of anti-AFP-treated mice this was accompanied by gross anatomical changes, including necrosis, more extensive than in the NRS-treated or other control mice. AFP blood levels roughly paralleled the tumor growth responses. Since an immunological response against the rabbit serum was elicited in the host, it is possible that circulating immune complexes play some role in tumor suppression. Changes observed in liver- and spleen-to-body weight ratios may also reflect a response to circulating immune complexes.
用兔抗鼠甲胎蛋白（AFP）抗血清以恒定剂量或递增剂量对携带BW7756肝癌的小鼠进行被动免疫。对照荷瘤小鼠接种生理盐水或非免疫兔血清（NRS）（恒定剂量或递增剂量），或不进行处理。接受恒定剂量或递增剂量抗AFP或恒定剂量NRS的小鼠的肿瘤生长曲线显示肝癌生长受到抑制；但在两组抗AFP治疗的小鼠中，均伴有大体解剖学变化，包括坏死，比NRS治疗组或其他对照小鼠更为广泛。AFP血液水平大致与肿瘤生长反应平行。由于宿主中引发了针对兔血清的免疫反应，因此循环免疫复合物可能在肿瘤抑制中发挥了一定作用。观察到的肝脏和脾脏与体重之比的变化也可能反映了对循环免疫复合物的反应。
