Sorem K A, Siler-Khodr T M
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, USA.
J Matern Fetal Med. 1998 Jan-Feb;7(1):1-7. doi: 10.1002/(SICI)1520-6661(199801/02)7:1<1::AID-MFM1>3.0.CO;2-S.
IGF-I, which is produced by intrauterine tissues including the placenta, has been implicated as a possible factor in intrauterine growth retardation (IUGR). We hypothesized that placental IGF-I production may be aberrant in pregnancies affected by IUGR. A placental perifusion system was utilized to study the release of IGF-I in placentas from normotensive severe IUGR (birthweight < 5%, (n = 9)) and normal control pregnancies (n = 5). For each placenta, tissues were perifused and samples were collected from hour 5 to hour 10. IGF-I was measured by radioimmunoassay after acid extraction. The cumulative release of total IGF-I from the control placentas from hour 5 to hour 10 of perifusion was 15,417 +/- 1,337 pg/g (mean +/- SEM), and decreased approximately 45% from hour 5 through hour 10 of perifusion. The pattern of IGF-I release, as well as the absolute mass of IGF-I, from six of the nine IUGR placentas was similar to the controls. However, three of the nine IUGR placentas demonstrated a significantly different IGF-I release pattern, i.e., IGF-I release did not decrease throughout the perifusion period. These three placentas also had abnormal absolute production rates of IGF-I, i.e., significantly elevated in one and significantly decreased in two. IGF-I production and release were normal in some IUGR placentas, although in certain cases of IUGR, the placental production and release pattern were aberrant. We conclude that abnormal regulation and production of IGF-I by the placenta may be a factor affecting certain pregnancies complicated by IUGR.
胰岛素样生长因子-I（IGF-I）由包括胎盘在内的子宫内组织产生，被认为可能是导致胎儿宫内生长受限（IUGR）的一个因素。我们推测，在受IUGR影响的妊娠中，胎盘IGF-I的产生可能异常。利用胎盘灌注系统研究了正常血压的严重IUGR（出生体重<5%，（n = 9））和正常对照妊娠（n = 5）的胎盘释放IGF-I的情况。对于每个胎盘，进行组织灌注，并在第5小时至第10小时收集样本。酸提取后通过放射免疫测定法测量IGF-I。在灌注的第5小时至第10小时，对照胎盘总IGF-I的累积释放量为15417±1337 pg/g（平均值±标准误），从灌注的第5小时到第10小时下降了约45%。9个IUGR胎盘中有6个的IGF-I释放模式以及IGF-I的绝对量与对照组相似。然而，9个IUGR胎盘中有3个表现出明显不同的IGF-I释放模式，即在整个灌注期IGF-I释放没有下降。这3个胎盘的IGF-I绝对产生率也异常，即1个显著升高，2个显著降低。在一些IUGR胎盘中，IGF-I的产生和释放是正常的，尽管在某些IUGR病例中，胎盘的产生和释放模式是异常的。我们得出结论，胎盘对IGF-I的调节和产生异常可能是影响某些并发IUGR妊娠的一个因素。
