涉及12号染色体p11 - 13、甲氨蝶呤代谢与儿童B祖细胞急性淋巴细胞白血病预后的易位：一项儿科肿瘤学组研究
Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
作者信息
Whitehead V M, Vuchich M J, Cooley L, Lauer S J, Mahoney D H, Shuster J J, Payment C, Bernstein M L, Akabutu J J, Bowen T, Kamen B A, Watson M S, Look A T, Pullen D J, Camitta B
机构信息
Penny Cole Hematology Research Laboratory, McGill University-Montreal Children's Hospital Research Institute, Quebec, Canada.
出版信息
Clin Cancer Res. 1998 Jan;4(1):183-8.
Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following diagnosis.
诊断时其淋巴母细胞积聚高水平甲氨蝶呤（MTX）和甲氨蝶呤多聚谷氨酸盐（MTXPGs）的B祖细胞急性淋巴细胞白血病患儿似乎预后良好。这归因于其原始细胞对MTX的敏感性增加。然而，治愈的B祖细胞急性淋巴细胞白血病患儿比例超过了其淋巴母细胞积聚高水平MTXPG的患儿数量。我们报告，染色体数<50且有涉及12号染色体短臂易位的患者的淋巴母细胞积聚低水平的MTXPGs。这些患者似乎有极佳的生存率，因为14例有影响12p易位的患者在诊断后26 - 79个月均未复发。
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