Jarvis L M, Bell H, Simmonds P, Hawkins A, Hellum K, Harthug S, Maeland A, Ritland S, Myrvang B, von der Lippe B, Raknerud N, Skaug K
Dept. of Medical Microbiology, University of Edinburgh, UK.
Scand J Gastroenterol. 1998 Feb;33(2):195-200. doi: 10.1080/00365529850166941.
Hepatitis G virus (HGV) or GBV-C is frequently detected in patients co-infected with hepatitis C virus (HCV). This study investigated host and virologic factors influencing the response to HGV/GBV-C to alpha-interferon treatment.
HGV/GBV-C was detected and quantified by nested polymerase chain reaction. The influence of variables such as liver biopsy appearance, liver function abnormalities, and response of HCV to interferon treatment was monitored.
Fourteen of the 25 HGV/GBV-C-infected patients treated with interferon (3-6 MIU three times a week for 6 months) became non-viraemic during treatment, although all relapsed after treatment withdrawal at 6 months, with no net change in virus load between 0 and 12 months.
Predictive factors for clearance of HGV/GBV-C viraemia by interferon were pre-treatment severity of liver disease (median Knodell score of 4, compared with 7 for non-responders; P = 0.030) and alanine aminotransferase levels (median, 114, 182 for non-responders; P = 0.039). Clearance was associated with the treatment response of HCV. Nine of 13 who cleared HGV/GBV-C also cleared HCV, compared with 3 of 11 HGV/GBV-C non-responders; P = 0.05). The shared susceptibility of HGV/GBV-C and HCV to interferon treatment suggests a link between the mechanism of clearance of the two viruses.
庚型肝炎病毒（HGV）或GBV-C在丙型肝炎病毒（HCV）合并感染患者中经常被检测到。本研究调查了影响HGV/GBV-C对α干扰素治疗反应的宿主和病毒学因素。
采用巢式聚合酶链反应检测和定量HGV/GBV-C。监测诸如肝活检表现、肝功能异常以及HCV对干扰素治疗反应等变量的影响。
25例接受干扰素治疗（3-6百万国际单位，每周3次，共6个月）的HGV/GBV-C感染患者中，14例在治疗期间病毒血症消失，尽管所有患者在6个月停药后均复发，0至12个月期间病毒载量无净变化。
干扰素清除HGV/GBV-C病毒血症的预测因素为治疗前肝病严重程度（Knodell评分中位数为4，无反应者为7；P = 0.030）和丙氨酸转氨酶水平（中位数，无反应者为182，清除者为114；P = 0.039）。清除与HCV的治疗反应相关。清除HGV/GBV-C的13例患者中有9例也清除了HCV，而11例HGV/GBV-C无反应者中有3例清除了HCV；P = 0.05）。HGV/GBV-C和HCV对干扰素治疗的共同易感性提示两种病毒的清除机制之间存在联系。
