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脑膜炎奈瑟菌与人类细胞外基质的结合

Binding to human extracellular matrix by Neisseria meningitidis.

作者信息

Eberhard T, Virkola R, Korhonen T, Kronvall G, Ullberg M

机构信息

Department of Laboratory Medicine, Karolinska Hospital, Stockholm, Sweden.

出版信息

Infect Immun. 1998 Apr;66(4):1791-4. doi: 10.1128/IAI.66.4.1791-1794.1998.

Abstract

Adhesion of Neisseria meningitidis strains to extracellular matrix (ECM) and purified matrix components was examined. Most strains bound to subendothelial ECM as well as to immobilized fibronectin and types I, III, and V collagen. Strains from healthy carriers adhered significantly better than isolates from patients. The binding site was localized to the central 75-kDa cell-binding domain of the fibronectin molecule. This domain has not been described previously to interact with bacterial structures.

摘要

检测了脑膜炎奈瑟菌菌株与细胞外基质(ECM)及纯化的基质成分的黏附情况。大多数菌株可黏附于内皮下ECM以及固定化的纤连蛋白、I型、III型和V型胶原蛋白。来自健康携带者的菌株黏附能力明显强于来自患者的分离株。黏附位点定位于纤连蛋白分子的中央75 kDa细胞结合结构域。此前尚未有该结构域与细菌结构相互作用的报道。

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本文引用的文献

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A Collagen-Binding S-Layer Protein in Lactobacillus crispatus.脆壁克鲁维酵母中的一种胶原结合 S-层蛋白。
Appl Environ Microbiol. 1995 Jul;61(7):2467-71. doi: 10.1128/aem.61.7.2467-2471.1995.
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Interaction of Haemophilus influenzae with the mammalian extracellular matrix.
J Infect Dis. 1996 May;173(5):1137-47. doi: 10.1093/infdis/173.5.1137.
6
Fibronectin structure and assembly.纤连蛋白的结构与组装。
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