Khare S D, Luthra H S, David C S
Department of Immunology, Mayo Clinic and Medical School, Rochester, MN 55905, USA.
Semin Immunol. 1998 Feb;10(1):15-23. doi: 10.1006/smim.1997.0101.
Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.
人类脊柱关节病与MHC I类等位基因HLA - B27的存在密切相关。脊柱关节病主要发生在男性中，通常由肠道细菌感染引发。与人类疾病相似，携带HLA - B27转基因的实验动物也会发生自发性炎症性疾病。除了HLA - B27，环境抗原在动物模型中的作用也已被涉及。细菌如何与HLA - B27相互作用尚不清楚。通过将HLA - B27转基因小鼠与各种转基因和基因敲除小鼠进行杂交，我们研究了这种炎症性疾病的免疫机制。在这篇综述中，我们将总结我们最近的发现并提出一个假说。
